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Aqua Bounty questions thoroughness of NRC study

January 20, 2004

WALTHAM, MA – Advanced hybrid salmon can reduce existing environmental risks in aquaculture and increase consumer benefits, says the developer of a high-tech salmon now under review by the U.S. Food and Drug Administration, but only the risks are reviewed in a new National Research Council report, Biological Confinement of Genetically Engineered Organisms.

AquAdvantage salmon hold considerable promise as a platform technology for sustainable aquaculture,” said Elliot Entis, the president of Aqua Bounty Technologies, Inc. “They make it possible to produce more food in less space, which conserves scarce coastal resources. They gain more weight using less fish feed and generating less waste, which conserves the fish feed resource and lowers nutrient loads in the water. They speed up the fallowing cycle on the farms which radically improves water quality. They make it possible to use more expensive sterile fish, which prevents escapees from becoming invasive. And they will help reduce the cost to U.S. consumers of heart-healthy seafood, which increases consumption among people who can’t afford to buy salmon today.”

“In America, we balance these public and environmental benefits against the very speculative risks reviewed in the NRC report,” Entis said. “Apparently the NRC authors prefer the European “Precautionary Principle” of scientifically-impossible zero risk.”

Noting that the NRC study committee included only one fisheries scientist, who works with inland species like pike and walleye, Entis noted that the salmon section of the study makes several very basic biological and economic errors. “Because the NRC authors do not understand the existing salmon industry, they discount the gains available from improving current aquaculture practices and overstate the potential for future impacts.”

The study suggests, for example, that sterile transgenic female salmon could mate with wild males, foreclosing on the next generation because the embryos would all die. But sterile female salmon do not even produce eggs, Entis said, so males could not be enticed to mate and waste their contribution to the next generation.

“This is exactly why we have proposed using sterile females,” Entis explained. “We know that sterile males can create an opportunity cost in the environment, but the females have absolutely no impact.”
Although the NRC authors were unable to find “appropriate research on the courtship and migratory behavior of triploid, all-female salmon,” Entis cited three scientific studies completed in Ireland just since 2000. The Irish studies found that sterile mixed sex salmon returned to their spawning rivers at a “fourfold lower rate” than fertile salmon and that only two-tenths of one percent of sterile females returned to the rivers at all. None of the females were fertile.

In addition to making errors of basic biology and conducting an insufficient literature review, Entis said the NRC authors apparently misunderstood ABT’s proposal to test each batch of sterilized salmon eggs to ensure the treatment is successful. “The NRC study suggests we plan to test a few eggs and cull any that are fertile,” Entis said. “In fact, we’re proposing to conduct a statistically credible sampling program that will test eggs from every mating and, if even a single fertile egg is found, the whole batch will be thrown away. This is the process already used for fish health testing.”

Entis questioned the study’s claim that “the cost of individual screening is a fraction of the current market price of salmon smolts…” “In fact,” he explained, “individual screening would virtually double the cost of smolts and push consumer prices so high that virtually all the economic benefits of this technology to the consumer would be lost.”

Entis said the company “welcomes all relevant research” into the performance of advanced salmon hybrids and re-iterated his commitment to release all environmental and food safety research conducted for the FDA review as soon as it is completed and found scientifically acceptable to the agency.

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